RAF Typhoon jets have joined forces with France's air force in a joint strike on an underground arms cache in Syrian territory used by the IS group, per a report from the UK's MoD.
The site, pinpointed through intelligence, was thought to be storing arms and explosives, the release indicated, and was situated in hills just north of Palmyra in central Syria.
"Our fighter planes used precision-guided Paveway IV munitions to strike a number of access tunnels down to the depot... initial indications indicate the strike was effective," the ministry announced.
There was no indication of any civilian casualties in the strike late on Saturday and all the aircraft returned to base without incident, the defence officials confirmed.
The Typhoon fighters were supported by a Voyager tanker plane.
IS - also known as Daesh - enforced jihadist rule over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This action underscores the UK's leading role, and determination to operate in unison with allied nations, to stamp out any revival of Daesh and their violent and radical beliefs in the Middle East," the British Defence Secretary the Defence Secretary said.
UK warplanes have performed patrols over Syria to "forestall any efforts to regroup" of IS following its routing at the Baghuz confrontation in the year 2019, the ministry said.
"I extend gratitude to the personnel of the UK armed forces participating in this operation for their expertise and their courage," he commented. "Including them were a great many British personnel on duty over Christmas and New Year. This operation, to eliminate terrorist threats who threaten our safety, demonstrates how our armed forces are ready to step up, throughout the year, keeping Britain secure within its borders and powerful internationally."
Last December, the United States armed forces carried out what it called a "major assault" on Daesh sites in Syria, after an attack claimed the lives of two US troops and a local interpreter in the Palmyra area.
The UN says Islamic State still boasts an estimated 5,000 to 7,000 fighters in Syria and Iraq.
